Breast Cancer Gene May Help In Predicting Risk of Family Members

A Polish study suggests that mutations in the CHEK2 gene signal a 34% increase in breast cancer risk if the patient’s family had a history of diagnosed breast cancer. The patients in the study who tested positive for this gene mutation and who had a mother and/or a sister with breast cancer were at the highest risk.

The gene indicates a 20% increase in risk to all women if mutations are found and the risk increases if the woman has a sister or mother with breast cancer to 34%, and 44% if other family members have also had breast cancer.

Woman with a family history are already encouraged to get screened for mutations in BRCA1. This would be further confirmation of the pending risk.